The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
Highlights • Lipid nanoparticles (LNPs) used for preclinical studies are highly inflammatory • The LNPs activate multiple inflammatory pathways and induce IL-1β and IL-6 • The LNPs’ inflammatory properties stem from their ionizable lipid component • The LNPs could be responsible for adjuvanticity and some of the side effects Summary Vaccines based on mRNA-containing lipid … Read more