Gain-of-function (GOF) research involves experimentation that aims or is expected to (and/or, perhaps, actually does) increase the transmissibility and/or virulence of pathogens.  Such research, when conducted by responsible scientists, usually aims to improve understanding of disease causing agents, their interaction with human hosts, and/or their potential to cause pandemics.  The ultimate objective of such research is to better inform public health and preparedness efforts and/or development of medical countermeasures.  Despite these important potential benefits, GOF research (GOFR) can pose risks regarding biosecurity and biosafety.  In 2014 the administration of US President Barack Obama called for a “pause” on funding (and relevant research with existing US Government funding) of GOF experiments involving influenza, SARS, and MERS viruses in particular.

Biosafety Expert Explains Why Fauci’s NIH ‘Gain-of-Function’ Testimony Was ‘Demonstrably False’

Gain of Function Research articles